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TV writer [[Andrew Goldberg (writer)|Andrew Goldberg]] and screenwriter-directors [[Jennifer Flackett]] and [[Mark Levin (director)|Mark Levin]] approached [[Nick Kroll]], Goldberg's best friend since childhood, with the idea to develop a show about going through puberty.<ref name="npr-freshair">{{cite news |last1=Gross |first1=Terry |title=Nick Kroll and John Mulaney Relive Raging Hormones and First Kisses in 'Big Mouth' |url=https://www.npr.org/2018/03/01/589841961/nick-kroll-and-john-mulaney-relive-raging-hormones-and-first-kisses-in-big-mouth |website=NPR.org |publisher=NPR |access-date=October 6, 2018 |archive-date=October 6, 2018 |archive-url=https://web.archive.org/web/20181006005116/https://www.npr.org/2018/03/01/589841961/nick-kroll-and-john-mulaney-relive-raging-hormones-and-first-kisses-in-big-mouth |url-status=live }}</ref> Kroll and Goldberg used their divergent pubertal experiences as a centerpiece of the show, because Kroll was a late bloomer while Goldberg went through the physical changes of puberty very early.<ref name="indiewire-wonderyears">{{cite web |last1=Schneider |first1=Michael |title='Big Mouth' Creator Nick Kroll on Convincing Netflix to Let Him Make a 'Perverted Wonder Years' — Turn It On Podcast |url=https://www.indiewire.com/2017/10/big-mouth-netflix-nick-kroll-season-one-turn-it-on-podcast-1201886638/ |website=IndieWire.com |date=October 12, 2017 |publisher=Indie Wire |access-date=October 6, 2018 |archive-date=October 6, 2018 |archive-url=https://web.archive.org/web/20181006075057/https://www.indiewire.com/2017/10/big-mouth-netflix-nick-kroll-season-one-turn-it-on-podcast-1201886638/ |url-status=live }}</ref> ''Big Mouth'' was also partially inspired to help aid teenagers in states with abstinence based sex education.<ref name="indiewire-wonderyears"/> Many of their lived experiences are featured in the show, such as Kroll's first kiss, and Goldberg's parents waxing his mustache.<ref name="npr-freshair" /> The show also includes an experience of their childhood friend, Lizzie, who the character of Jessi is based on, getting her first period on a school trip to the Statue of Liberty. According to Kroll in an interview on [[NPR]], ''Big Mouth'' "takes an equal look at what it's like for girls and women, the process of going through puberty, which I think has not been quite as explored in most popular culture."<ref name="npr-freshair" /> Netflix announced they had picked up ''Big Mouth'' in June 2016.<ref name="deadline-netflixorder">{{cite web |last1=Andreeva |first1=Nellie |title=Netflix Orders 'Big Mouth' Animated Series From Nick Kroll & Andrew Goldberg |url=https://deadline.com/2016/06/netflix-big-mouth-animated-series-nick-kroll-andrew-goldberg-john-mulaney-1201771662/ |website=Deadline.com |date=June 13, 2016 |access-date=October 6, 2018 |archive-date=August 27, 2018 |archive-url=https://web.archive.org/web/20180827142251/https://deadline.com/2016/06/netflix-big-mouth-animated-series-nick-kroll-andrew-goldberg-john-mulaney-1201771662/ |url-status=live }}</ref>
TV writer [[Andrew Goldberg (writer)|Andrew Goldberg]] and screenwriter-directors [[Jennifer Flackett]] and [[Mark Levin (director)|Mark Levin]] approached [[Nick Kroll]], Goldberg's best friend since childhood, with the idea to develop a show about going through puberty.<ref name="npr-freshair">{{cite news |last1=Gross |first1=Terry |title=Nick Kroll and John Mulaney Relive Raging Hormones and First Kisses in 'Big Mouth' |url=https://www.npr.org/2018/03/01/589841961/nick-kroll-and-john-mulaney-relive-raging-hormones-and-first-kisses-in-big-mouth |website=NPR.org |publisher=NPR |access-date=October 6, 2018 |archive-date=October 6, 2018 |archive-url=https://web.archive.org/web/20181006005116/https://www.npr.org/2018/03/01/589841961/nick-kroll-and-john-mulaney-relive-raging-hormones-and-first-kisses-in-big-mouth |url-status=live }}</ref> Kroll and Goldberg used their divergent pubertal experiences as a centerpiece of the show, because Kroll was a late bloomer while Goldberg went through the physical changes of puberty very early.<ref name="indiewire-wonderyears">{{cite web |last1=Schneider |first1=Michael |title='Big Mouth' Creator Nick Kroll on Convincing Netflix to Let Him Make a 'Perverted Wonder Years' — Turn It On Podcast |url=https://www.indiewire.com/2017/10/big-mouth-netflix-nick-kroll-season-one-turn-it-on-podcast-1201886638/ |website=IndieWire.com |date=October 12, 2017 |publisher=Indie Wire |access-date=October 6, 2018 |archive-date=October 6, 2018 |archive-url=https://web.archive.org/web/20181006075057/https://www.indiewire.com/2017/10/big-mouth-netflix-nick-kroll-season-one-turn-it-on-podcast-1201886638/ |url-status=live }}</ref> ''Big Mouth'' was also partially inspired to help aid teenagers in states with abstinence based sex education.<ref name="indiewire-wonderyears"/> Many of their lived experiences are featured in the show, such as Kroll's first kiss, and Goldberg's parents waxing his mustache.<ref name="npr-freshair" /> The show also includes an experience of their childhood friend, Lizzie, who the character of Jessi is based on, getting her first period on a school trip to the Statue of Liberty. According to Kroll in an interview on [[NPR]], ''Big Mouth'' "takes an equal look at what it's like for girls and women, the process of going through puberty, which I think has not been quite as explored in most popular culture."<ref name="npr-freshair" /> Netflix announced they had picked up ''Big Mouth'' in June 2016.<ref name="deadline-netflixorder">{{cite web |last1=Andreeva |first1=Nellie |title=Netflix Orders 'Big Mouth' Animated Series From Nick Kroll & Andrew Goldberg |url=https://deadline.com/2016/06/netflix-big-mouth-animated-series-nick-kroll-andrew-goldberg-john-mulaney-1201771662/ |website=Deadline.com |date=June 13, 2016 |access-date=October 6, 2018 |archive-date=August 27, 2018 |archive-url=https://web.archive.org/web/20180827142251/https://deadline.com/2016/06/netflix-big-mouth-animated-series-nick-kroll-andrew-goldberg-john-mulaney-1201771662/ |url-status=live }}</ref>


On June 24, 2020, it was announced that [[Jenny Slate]] decided to step down from voicing Missy Foreman-Greenwald so that a Black actress could have the role in the wake of the [[George Floyd protests]].<ref name="missyrecast">{{cite web|url=https://variety.com/2020/tv/news/jenny-slate-big-mouth-missy-1234648600/|title=Jenny Slate to stop playing Missy in 'Big Mouth'|date=June 24, 2020|access-date=June 24, 2020|archive-date=June 24, 2020|archive-url=https://web.archive.org/web/20200624225457/https://variety.com/2020/tv/news/jenny-slate-big-mouth-missy-1234648600/|url-status=live}}</ref> Slate's final time voicing Missy is in the fourth season as she recorded her lines in advance.<ref>{{cite web|url=https://www.cartoonbrew.com/artist-rights/jenny-slate-and-kristen-bell-will-stop-voicing-black-characters-on-big-mouth-and-central-park-193635.html|title=Jenny Slate And Kristen Bell Will Stop Voicing Black Characters On 'Big Mouth' And 'Central Park'|first=Alex Dudok|last=De Wit|work=Cartoon Brew|date=June 25, 2020|access-date=June 25, 2020|archive-date=June 25, 2020|archive-url=https://web.archive.org/web/20200625152325/https://www.cartoonbrew.com/artist-rights/jenny-slate-and-kristen-bell-will-stop-voicing-black-characters-on-big-mouth-and-central-park-193635.html|url-status=live}}</ref> On August 28, 2020, it was reported that [[Ayo Edebiri]] was cast to replace Slate as Missy. Her first appearance as Missy is in "Horrority House", the penultimate episode of the fourth season.<ref name="AyoE">{{cite web|url=https://variety.com/2020/tv/news/big-mouth-ayo-edebiri-new-missy-jenny-slate-season-4-1234748675/|title='Big Mouth': Ayo Edebiri to Replace Jenny Slate as Missy (EXCLUSIVE)|website=Variety|first=Danielle|last=Turchiano|date=August 28, 2020|access-date=August 28, 2020|archive-date=August 28, 2020|archive-url=https://web.archive.org/web/20200828150012/https://variety.com/2020/tv/news/big-mouth-ayo-edebiri-new-missy-jenny-slate-season-4-1234748675/|url-status=live}}</ref> On April 24, 2023, Netflix renewed the series for an eighth and final season.<ref>{{Cite web|url=https://deadline.com/2023/04/big-mouth-renewed-season-8-final-season-human-resources-end-season-2-netflix-1235333560/|title='Big Mouth' Renewed For 8th & Final Season By Netflix; Spinoff 'Human Resources' To End With Season 2|work=Deadline Hollywood|first=Nellie|last=Andreeva|date=April 24, 2023|access-date=April 24, 2023|archive-date=April 24, 2023|archive-url=https://web.archive.org/web/20230424194126/https://deadline.com/2023/04/big-mouth-renewed-season-8-final-season-human-resources-end-season-2-netflix-1235333560/|url-status=live}}</ref> In April 2024, Netflix confirmed that the eighth and final season is set to air in 2025.<ref>{{cite news|url=https://www.whats-on-netflix.com/news/big-mouth-season-8-final-season-to-release-on-netflix-in-2025/|title=Big Mouth’ Season 8: Final Episodes to Release on Netflix in 2025|publisher=What's on Netflix|date=April 22, 2024|access-date=May 17, 2024}}</ref>
On June 24, 2020, [[Jenny Slate]]